Genetic interactions with Rap1 and Ras1 reveal a second function for the Fat facets deubiquitinating enzyme in Drosophila eye development

被引:27
作者
Li, QH
Hariharan, IK
Chen, FL
Huang, YZ
Fischer, JA
机构
[1] UNIV TEXAS,DEPT ZOOL,INST MOL & CELLULAR BIOL,AUSTIN,TX 78712
[2] HARVARD UNIV,SCH MED,MASSACHUSETTS GEN HOSP,CTR CANC,CHARLESTOWN,MA 02129
关键词
D O I
10.1073/pnas.94.23.12515
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Drosophila fat facets gene encodes a deubiquitinating enzyme that regulates a cell communication pathway essential very early in eye development, prior to facet assembly, to limit the number of photoreceptor cells in each facet of the compound eye to eight. The Fat facets protein facilitates the production of a signal in cells outside the developing facets that inhibits neural development of particular facet precursor cells. Novel gain-of-function mutations in the Drosophila Rap1 and Ras1 genes are described herein that interact genetically with fat facets mutations. Analysis of these genetic interactions reveals that Fat facets has an additional function later in eye development involving Rap1 and Ras1 proteins. Moreover, the results suggest that undifferentiated cells outside the facet continue to influence facet assembly later in eye development.
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收藏
页码:12515 / 12520
页数:6
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