A specialized mitochondrial molecular chaperone system: A role in formation of Fe/S centers

被引：76

作者：

Craig, EA

Marszalek, J

机构：

[1] Univ Wisconsin, Dept Biomol Chem, Madison, WI 53706 USA

[2] Univ Gdansk, Fac Biotechnol, Dept Mol & Cellular Biol, PL-80822 Gdansk, Poland

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2002年 / 59卷 / 10期

关键词：

mitochondria; Hsp70; Fe/S center; iron; Jac; 1; Ssq; molecular chaperone;

D O I：

10.1007/PL00012493

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria contain a specialized system of molecular chaperones that plays a critical role in the biogenesis of Fe/S centers. This Hsp70:J-protein system shows many similarities to the system found in bacteria, but the precise role of neither chaperone system has been defined. However, evidence to date suggests an interaction with the scaffold protein on which a transient Fe/S center is assembled, and thus implies a role in either assembly of the center or its transfer to recipient proteins.

引用

页码：1658 / 1665

页数：8

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