Bioinorganic Magnetic Core-Shell Nanocomposites Carrying Antiarthritic Agents: Intercalation of Ibuprofen and Glucuronic Acid into Mg-Al-Layered Double Hydroxides Supported on Magnesium Ferrite

被引：109

作者：

Ay, Ahmet Nedm ^{[1
]}

Zumreoglu-Karan, Birguel ^{[1
]}

Temel, Abidin ^{[2
]}

Rives, Vicente ^{[3
]}

机构：

[1] Hacettepe Univ, Dept Chem, TR-06800 Ankara, Turkey

[2] Hacettepe Univ, Dept Geol Engn, TR-06800 Ankara, Turkey

[3] Univ Salamanca, Dept Quim Inorgan, GIR QUESCAT, E-37008 Salamanca, Spain

来源：

INORGANIC CHEMISTRY | 2009年 / 48卷 / 18期

关键词：

HYDROTALCITE-LIKE COMPOUNDS; ANIONIC CLAYS; STOICHIOMETRIC SYNTHESIS; RELEASE; SOLUBILITY; DRUGS; LDH;

D O I：

10.1021/ic901097a

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

This paper describes the synthesis and characterization of a composite constituted by an antiarthritic agent (AA) intercalated into a layered double hydroxide (LDH) supported on magnesium ferrite. Core-shell nanocomposites were prepared by depositing Mg-Al-NO3-LDH on a MgFe2O4 core prepared by calcination of a nonstoichiometric Mg-Fe-CO3-LDH. Intercalation of ibuprofen and glucuronate anions was performed by ion-exchange with nitrate ions. The structural characteristics of the obtained products were investigated by powder X-ray diffraction, element chemical analysis, Fourier transform infrared spectroscopy, and thermogravimetric analysis. Morphologies of the nanocomposite particles were examined by scanning electron microscopy and transmission electron microscopy. The products were shown to intercalate substantial amounts of AA with enhanced thermal stabilities. Room-temperature magnetic measurements by vibrating sample magnetometry revealed that the products show soft ferromagnetic properties suitable for potential utilization in magnetic arthritis therapy.

引用

页码：8871 / 8877

页数：7

共 44 条

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