An in vitro method for assessing biomaterial-associated platelet activation

被引：6

作者：

不详

机构：

[1] Department of General Surgery, University of Michigan, Ann Arbor, MI

[2] MC3 Corporation, University of Michigan, Ann Arbor, MI

[3] Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI

[4] Department of Pediatrics and Communicable Diseases, University of Michigan Health System, F-6884 Mott/0243, Ann Arbor, MI 48109-0243

来源：

ASAIO JOURNAL | 2007年 / 53卷 / 02期

关键词：

D O I：

10.1097/MAT.0b013e318031121f

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

The development of a nonthrombogenic artificial surface for use with indwelling sensors or catheters remains an elusive goal despite decades of ongoing research. In vivo studies are both labor intensive and costly, and are therefore an inefficient way to rapidly screen possible surface materials. The following in vitro model used glass, polyvinyl chloride (PVC), and polypropylene test tubes incubated with In-labeled rabbit platelets and illustrated that, despite equivalent platelet count and function, platelet adhesion was greatest on glass (n = 13), with PVC (n = 17) at 67 ± 8% and polypropylene (n = 13) at 43 ± 5% when compared with glass. Extrapolating this method by coating test tubes with new, nonthrombogenic materials is a quick and reliable way to screen material before embarking upon more lengthy in vivo animal studies. ©2007Amercian Society of Artificial Internal Organs.

引用

页码：159 / 162

页数：4

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