Renal hemodynamic changes induced by captopril and angiotensin-converting enzyme gene polymorphism

被引：33

作者：

Mizuiri, S

Hemmi, H

Inoue, A

Takano, M

Kadomatsu, S

Tanimoto, H

Tanegashima, M

Hayashi, I

Fushimi, T

Hasegawa, A

机构：

[1] TOHO UNIV,SCH MED,DEPT MOL BIOL,TOKYO 143,JAPAN

[2] TOHO UNIV,SCH MED,CENT RADIONUCL MED LAB,TOKYO 143,JAPAN

来源：

NEPHRON | 1997年 / 75卷 / 03期

关键词：

renal hemodynamic changes; captopril; angiotensin-converting enzyme; gene polymorphism;

D O I：

10.1159/000189554

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We studied the relationship between renal hemodynamic changes induced by a single acute administration of captopril (50 mg p.o.) and angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in 27 healthy human volunteers, 7 with DD genotype, 10 with ID, and 10 with II genotype. The increase in effective renal plasma flow (p < 0.02) and the fall in renal vascular resistance (p < 0.01) in response to captopril were significantly less in subjects with the DD genotype than in subjects with the other genotypes. These data suggest that intrarenal ACE inhibition by captopril differs according to ACE gene ID polymorphism in healthy humans.

引用

页码：310 / 314

页数：5

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