Human milk oligosaccharides: prebiotics and beyond

被引：218

作者：

Bode, Lars ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Div Neonatol, Dept Pediat, San Diego, CA 92103 USA

来源：

NUTRITION REVIEWS | 2009年 / 67卷 / 11期

关键词：

human milk oligosaccharides; infant formula; prebiotics; ACTIVATING-FACTOR-ACETYLHYDROLASE; 1ST; 6; MONTHS; NECROTIZING ENTEROCOLITIS; DC-SIGN; INFANTS; FORMULA; DIARRHEA; RISK; HIV; SUPPLEMENTATION;

D O I：

10.1111/j.1753-4887.2009.00239.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Human milk oligosaccharides (HMO) are complex glycans that are present at very high concentrations in human milk but not in infant formula. The significant energy expended by mothers to make these complex glycans suggests they must be important. How do maternal HMOs benefit the breast-fed infant? How are HMOs synthesized in the human mammary gland? How can we provide formula-fed infants with HMOs or HMO-like glycans? This article reviews current knowledge and open questions on the biosynthesis and functions of HMOs.

引用

页码：S183 / S191

页数：9

共 39 条

[1] Glycoprofiling with micro-arrays of glycoconjugates and lectins
Angeloni, S
Ridet, JL
Kusy, N
Gao, H
Crevoisier, F
Guinchard, S
Kochhar, S
Sigrist, H
Sprenger, N
[J]. GLYCOBIOLOGY, 2005, 15 (01) : 31 - 41
[2] Early supplementation of prebiotic oligosaccharides protects formula-fed infants against infections during the first 6 months of life
Arslanoglu, Sertac
Moro, Guido E.
Boehm, Gunther
[J]. JOURNAL OF NUTRITION, 2007, 137 (11) : 2420 - 2424
[3] Inhibition of monocyte, lymphocyte, and neutrophil adhesion to endothelial cells by human milk oligosaccharides
Bode, L
Kunz, C
Muhly-Reinholz, M
Mayer, K
Seeger, W
Rudloff, S
[J]. THROMBOSIS AND HAEMOSTASIS, 2004, 92 (06) : 1402 - 1410
[4] Human milk oligosaccharides reduce platelet-neutrophil complex formation leading to a decrease in neutrophil β2 integrin expression
Bode, L
Rudloff, S
Kunz, C
Strobel, S
Klein, N
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 76 (04) : 820 - 826
[5] The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis
Caplan, MS
Lickerman, M
Adler, L
Dietsch, GN
Yu, A
[J]. PEDIATRIC RESEARCH, 1997, 42 (06) : 779 - 783
[6] The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis
Caplan, MS
Jilling, T
[J]. LIPIDS, 2001, 36 (09) : 1053 - 1057
[7] The effect of a prebiotic supplemented formula on growth and stool microbiology of term infants
Costalos, C.
Kapiki, A.
Apostolou, M.
Papathoma, E.
[J]. EARLY HUMAN DEVELOPMENT, 2008, 84 (01) : 45 - 49
[8] RISK OF DIARRHEA DURING THE 1ST YEAR OF LIFE ASSOCIATED WITH INITIAL AND SUBSEQUENT COLONIZATION BY SPECIFIC ENTEROPATHOGENS
CRAVIOTO, A
REYES, RE
TRUJILLO, F
URIBE, F
NAVARRO, A
DELAROCA, JM
HERNANDEZ, JM
PEREZ, G
VAZQUEZ, V
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 131 (05) : 886 - 904
[9] Prevention of mother-to-child HIV transmission in resource-poor countries - Translating research into policy and practice
De Cock, KM
Fowler, MG
Mercier, E
de Vincenzi, I
Saba, J
Hoff, E
Alnwick, DJ
Rogers, M
Shaffer, N
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (09): : 1175 - 1182
[10] FURUKAWA M, 1993, J LIPID RES, V34, P1603

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