Imaging stem cells implanted in infarcted myocardium

被引:84
作者
Zhou, Rong
Acton, Paul D.
Ferrari, Victor A.
机构
[1] Univ Penn, Dept Radiol, Mol Imaging Labs, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Cardiovasc Med, Philadelphia, PA 19104 USA
[3] Thomas Jefferson Univ, Dept Radiol, Philadelphia, PA 19107 USA
关键词
D O I
10.1016/j.jacc.2006.08.026
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Stem cell-based cellular cardiomyoplasty represents a promising therapy for myocardial infarction. Noninvasive imaging techniques would allow the evaluation of survival, migration, and differentiation status of implanted stem cells in the same subject over time. This review describes methods for cell visualization using several corresponding noninvasive imaging modalities, including magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and bioluminescent imaging. Reporter-based cell visualization is compared with direct cell labeling for short- and long-term cell tracking.
引用
收藏
页码:2094 / 2106
页数:13
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