Proteomic Analysis of Alzheimer's Disease Cerebrospinal Fluid from Neuropathologically Diagnosed Subjects

被引：24

作者：

Maarouf, Chera L. ^{[1
]}

Andacht, Tracy M. ^{[2
]}

Kokjohn, Tyler A. ^{[1
,3
]}

Castano, Eduardo M. ^{[4
]}

Sue, Lucia I. ^{[5
]}

Beach, Thomas G. ^{[5
]}

Roher, Alex E. ^{[1
]}

机构：

[1] Sun Hlth Res Inst, Longtine Ctr Mol Biol & Genet, Sun City, AZ 85351 USA

[2] Univ Georgia, Dept Chem, Athens, GA 30602 USA

[3] Midwestern Univ, Dept Microbiol, Glendale, AZ 85308 USA

[4] Fdn Inst Leloir, Buenos Aires, DF, Argentina

[5] Sun Hlth Res Inst, WH Civin Lab Neuropathol, Sun City, AZ 85351 USA

来源：

CURRENT ALZHEIMER RESEARCH | 2009年 / 6卷 / 04期

关键词：

Alzheimer's disease; cerebrospinal fluid; proteomics; DIGE; biomarkers; NEURON-SPECIFIC ENOLASE; AMYLOID BETA-PROTEIN; POSTMORTEM CHANGES; APOLIPOPROTEIN-E; CATHEPSIN-D; DEMENTIA; TAU; BIOMARKERS; DEGENERATION; POLYMORPHISM;

D O I：

10.2174/156720509788929318

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the clinical diagnosis and differentiation of this dementia from other pathologies have confounded biomarker studies in antemortem CSF samples. Using postmortem ventricular CSF (V-CSF) pools, two-dimensional difference gel electrophoresis (2D DIGE) analyses revealed a set of proteins that showed significant differences between neuropathologically-diagnosed AD and elderly nondemented controls (NDC), as well as subjects with non-AD dementias. The 2D DIGE system identified a set of 21 different protein biomarkers. This panel of proteins probably reflects fundamental pathological changes that are divergent from both normal aging and non-AD dementias.

引用

页码：399 / 406

页数：8

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