Development of the locomotor network in zebrafish

被引:292
作者
Drapeau, P [1 ]
Saint-Amant, L
Buss, RR
Chong, M
McDearmid, JR
Brustein, E
机构
[1] McGill Univ, McGill Ctr Res Neurosci, Montreal, PQ H3G 1A4, Canada
[2] McGill Univ, Dept Biol, Montreal, PQ H3G 1A4, Canada
[3] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3G 1A4, Canada
基金
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词
D O I
10.1016/S0301-0082(02)00075-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The zebrafish is a leading model for studies of vertebrate development and genetics. Its embryonic motor behaviors are easy to assess (e.g. for mutagenic screens). the embryos develop rapidly (hatching as larvae at 2 days) and are transparent, permitting calcium imaging and patch clamp recording in vivo. We review primarily the recent advances in understanding the cellular basis for the development of motor activities in the developing zebrafish. The motor activities are generated largely in the spinal cord and hindbrain. In the embryo these segmented structures possess a relatively small number of repeating sets of identifiable neurons. Many types of neurons as well as the two types of muscle cells have been classified based on their morphologies. Some of the molecular signals for cellular differentiation have been identified recently and mutations affecting cell development have been isolated. Embryonic motor behaviors appear in sequence and consist of an early period of transient spontaneous coiling contractions, followed by the emergence of twitching responses to touch, and later by the ability to swim. Coiling contractions are generated b) an electrically coupled network of a subset of spinal neurons whereas a chemical (glutamatergic and glycinergic) synaptic drive underlies touch responses and swimming. Swimming becomes sustained in larvae once the neuromodulatory serotonergic system develops, These results indicate many similarities between developing zebrafish and other vertebrates in the properties of the synaptic drive underlying locomotion. Therefore, the zebrafish is a useful preparation for gaining new insights into the development of the neural control of vertebrate locomotion. As the types of neurons, transmitters, receptors and channels used in the locomotor network are being defined, this open, the possibility of combining cellular neurophysiology with forward and reverse molecular genetics to understand the principles of locomotor network assembly and function. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:85 / 111
页数:27
相关论文
共 283 条
[1]   Properties of miniature glutamatergic EPSCs in neurons of the locomotor regions of the developing zebrafish [J].
Ali, DW ;
Buss, RR ;
Drapeau, P .
JOURNAL OF NEUROPHYSIOLOGY, 2000, 83 (01) :181-191
[2]   Development of spontaneous glycinergic currents in the Mauthner neuron of the zebrafish embryo [J].
Ali, DW ;
Drapeau, P ;
Legendre, P .
JOURNAL OF NEUROPHYSIOLOGY, 2000, 84 (04) :1726-1736
[3]   EMBRYONIC EXPRESSION AND DNA-BINDING PROPERTIES OF ZEBRAFISH PAX-6 [J].
AMIRTHALINGAM, K ;
LORENS, JB ;
SAETRE, BO ;
SALANECK, E ;
FJOSE, A .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 215 (01) :122-128
[4]   A large-scale insertional mutagenesis screen in zebrafish [J].
Amsterdam, A ;
Burgess, S ;
Golling, G ;
Chen, WB ;
Sun, ZX ;
Townsend, K ;
Farrington, S ;
Haldi, M ;
Hopkins, N .
GENES & DEVELOPMENT, 1999, 13 (20) :2713-2724
[5]  
Appel B, 2000, DEV DYNAM, V219, P155, DOI 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1052>3.3.CO
[6]  
2-B
[7]  
Appel B, 1998, DEVELOPMENT, V125, P371
[8]   Buffering intracellular calcium disrupts motoneuron development in intact zebrafish embryos [J].
Ashworth, R ;
Zimprich, F ;
Bolsover, SR .
DEVELOPMENTAL BRAIN RESEARCH, 2001, 129 (02) :169-179
[9]   THE EFFECTS OF SEROTONERGIC DRUGS ON THE LOCOMOTOR PATTERN AND ON CUTANEOUS REFLEXES OF THE ADULT CHRONIC SPINAL CAT [J].
BARBEAU, H ;
ROSSIGNOL, S .
BRAIN RESEARCH, 1990, 514 (01) :55-67
[10]  
Barresi MJF, 2000, DEVELOPMENT, V127, P2189