Enhancement of nestin protein-immunoreactivity induced by ionizing radiation in the forebrain ependymal regions of rats

被引：28

作者：

Shi, M

Wei, LC

Cao, R

Chen, LW ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Radiotherapy, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China

来源：

NEUROSCIENCE RESEARCH | 2002年 / 44卷 / 04期

基金：

中国国家自然科学基金;

关键词：

nestin; ionizing radiation; intermediate filament; ependyma; brain; rat;

D O I：

10.1016/S0168-0102(02)00175-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression of nestin was immunohistochemically examined in the forebrains of rats receiving ionizing radiation. Nestin-immunoreactive cells were predominately distributed in ependymal regions. Nestin-immunoreactivity in ependymal regions of irradiated rats increased significantly from 1 to 4 weeks after ionizing radiation compared with that of controls. Double immunofluorescence confirmed that about 94% of nestin-positive cells exhibited glial fibrillary acidic protein-immunoreactivity and a minor population of them showed Ki-67-immunoreactivity in these regions. The results have provided evidence for up-regulation of nestin expression induced by ionizing radiation in ependymal cells, suggesting that these reactive ependymal cells may be involved in remodeling and repairing processes of brain irradiation injury. (C) 2002 Elsevier Science Ireland Ltd. and the Japan Neuroscience Society. All rights reserved.

引用

页码：475 / 481

页数：7

共 32 条

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[2] Apoptosis is induced in the subependyma of young adult rats by ionizing irradiation [J].