Cognitive and behavioral effects of quetiapine in Alzheimer disease patients

被引：39

作者：

Scharre, DW ^{[1
]}

Chang, SI ^{[1
]}

机构：

[1] Ohio State Univ, Dept Neurol, Div Cognit Neurol, Columbus, OH 43210 USA

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2002年 / 16卷 / 02期

关键词：

quetiapine; Alzheimer disease; behaviors; psychosis; aggression; cognition;

D O I：

10.1097/00002093-200204000-00011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a prospective, open-label, 12-week pilot study in outpatients with probable Alzheimer disease (AD) with psychosis or aggressive behaviors, we used the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and the Neuropsychiatric Inventory (NPI) to evaluate the cognitive and behavioral effects of quetiapine. After receiving doses ranging from 50 to 150 mg, patients given quetiapine showed a significant decrease of delusions, aggression, and overall behaviors based on NPI scores at 6 and 12 weeks. ADAS-cog scores did not show a significant change over 12 weeks. This study provides initial evidence that quetiapine does not significantly worsen cognition in AD outpatients.

引用

页码：128 / 130

页数：3

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