Chemokine receptor expression on mucosal dendritic cells from the endocervix of healthy women

被引：27

作者：

Prakash, M

Kapembwa, MS

Gotch, F

Patterson, S

机构：

[1] Chelsea & Westminster Hosp, Imperial Coll Sci Technol & Med, Fac Med, Dept Immunol, London, England

[2] Northwick Pk Hosp & Clin Res Ctr, Imperial Coll Sci Technol & Med, Dept GU HIV Med, Harrow HA1 3UJ, Middx, England

[3] St Marks Hosp, Imperial Coll Sci Technol & Med, Dept GU HIV Med, Harrow, Middx, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2004年 / 190卷 / 02期

关键词：

D O I：

10.1086/422034

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) may be an initial target of human immunodeficiency virus (HIV) during heterosexual transmission. An analysis of DCs in the intraepithelial layer of the endocervix of the female genital tract from healthy women showed that similar to20% expressed CD1a, and 30% expressed cutaneous leukocyte antigen (CLA). Langerin, a molecule associated with Langerhans DCs, was on CD1a-positive and - negative DCs and on CLA-positive cells. CCR5 and CXCR4 were detected on CD1a-positive and - negative cervical DCs. These findings suggest that DCs in the genital tract are potential targets for macrophage-tropic and lymphotropic strains of HIV.

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页码：246 / 250

页数：5

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