Of mice and men: species variations of toll-like receptor expression

被引：262

作者：

Rehli, M ^{[1
]}

机构：

[1] Univ Hosp Regensburg, Dept Hematol & Oncol, D-93042 Regensburg, Germany

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 08期

关键词：

D O I：

10.1016/S1471-4906(02)02259-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) comprise a family of evolutionary conserved pattern recognition molecules that have an essential role in mammalian innate immune defense. Recent observations suggest that several TLR orthologues are expressed differently in mice and humans-variations among both species include the expression of TLR transcripts in different cell types and different transcription regulation on cellular activation. Apparently some TLR genes have been placed into a completely different regulatory context during evolution. It will be interesting and important to clarify whether the observed regulatory differences influence innate immune responses in a species-specific manner.

引用

页码：375 / 378

页数：4

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