Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample

被引：120

作者：

Agrawal, Arpana

Edenberg, Howard J.

Foroud, Tatiana

Bierut, Laura J.

Dunne, Gerald

Hinrichs, Anthony L.

Nurnberger, John I.

Crowe, Raymond

Kuperman, Samuel

Schuckit, Marc A.

Begleiter, Henri

Porjesz, Bernice

Dick, Danielle M.

机构：

[1] Washington Univ, Dept Psychiat, St Louis, MO 63130 USA

[2] Indiana Univ, Sch Med, Indianapolis, IN 46204 USA

[3] Univ Iowa, Iowa City, IA 52242 USA

[4] Univ Calif San Diego, La Jolla, CA 92093 USA

[5] SUNY, New York, NY USA

来源：

BEHAVIOR GENETICS | 2006年 / 36卷 / 05期

基金：

美国国家卫生研究院;

关键词：

alcoholism; association analyses; COGA; drug dependence; GABRA2; PDT;

D O I：

10.1007/s10519-006-9069-4

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABA(A) receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABA(A) cluster on chromosome 4 with illicit drug dependence.

引用

页码：640 / 650

页数：11

共 57 条

[1] Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach [J].