Neurotrophins and dementia -: Keeping in touch

被引：16

作者：

Castren, Eero ^{[1
]}

Tanila, Heikki

机构：

[1] Univ Helsinki, Neurosci Ctr, Sigrid Juselius Lab Mol Neurosci, Helsinki 00014, Finland

[2] Univ Kuopio, AI Virtanen Inst, Dept Neurobiol, Kuopio 70211, Finland

来源：

NEURON | 2006年 / 51卷 / 01期

关键词：

D O I：

10.1016/j.neuron.2006.06.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Down's syndrome patients develop dementia similar to Alzheimer's disease and show elevated levels of amyloid precursor protein in brain. Two papers in this issue of Neuron show that reduced retrograde transport or signaling of the neurotrophins NGF or BDNF, respectively, may account for the neuronal pathology in mouse models of Down's syndrome.

引用

页码：1 / 3

页数：3

共 12 条

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[2] Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion [J].

Cooper, JD ;

Salehi, A ;

Delcroix, JD ;

Howe, CL ;

Belichenko, PV ;

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[3] Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16 [J].

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Renn, Cynthia L. ;

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NEURON, 2006, 51 (01) :21-28

[5] BDNF and full-length and truncated TrkB expression in Alzheimer disease.: Implications in therapeutic strategies [J].

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[7] Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCγ pathway, reduced anxiety, and facilitated learning [J].

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Castrén, E .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2004, 26 (01) :166-181

[8]

Saarelainen T, 2000, SYNAPSE, V38, P102, DOI 10.1002/1098-2396(200010)38:1<102::AID-SYN11>3.0.CO

[9]

2-K

[10] Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration [J].

Salehi, Ahmad ;

Delcroix, Jean-Dominique ;

Belichenko, Pavel V. ;

Zhan, Ke ;

Wu, Chengbiao ;

Valletta, Janice S. ;

Takimoto-Kimura, Ryoko ;

Kleschevnikov, Alexander M. ;

Sambamurti, Kumar ;

Chung, Peter P. ;

Xia, Weiming ;

Villar, Angela ;

Campbell, William A. ;

Kulnane, Laura Shapiro ;

Nixon, Ralph A. ;

Lamb, Bruce T. ;

Epstein, Charles J. ;

Stokin, Gorazd B. ;

Goldstein, Lawrence S. B. ;

Mobley, William C. .

NEURON, 2006, 51 (01) :29-42

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