An update on the use of antibodies against the filoviruses

被引：3

作者：

Saphire, Erica Ollmann ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

IMMUNOTHERAPY | 2013年 / 5卷 / 11期

关键词：

antibody; antibody cocktail; Ebola virus; ebolavirus; filovirus; glycoprotein; GP; immunotherapeutic; Marburg virus; marburgvirus; postexposure; EBOLA-VIRUS GLYCOPROTEIN; NIEMANN-PICK C1; MONOCLONAL-ANTIBODIES; ZAIRE-EBOLAVIRUS; FRUIT BATS; STANDARDIZED NOMENCLATURE; RESTON EBOLAVIRUS; CRYSTAL-STRUCTURE; ENTRY REQUIRES; SPECIES LEVEL;

D O I：

10.2217/IMT.13.124

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple recent, independent studies have confirmed that passively administered antibodies can provide effective postexposure therapy in nonhuman primates after exposure to an otherwise lethal dose of Ebola virus or Marburg virus. In this article, we review composition and performance of the antibody cocktails tested thus far, what is known about antibody epitopes on the viral glycoprotein target and ongoing research questions in further development of such cocktails for pre-exposure or emergency postexposure use.

引用

页码：1221 / 1233

页数：13

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