Prognostic value of plasma interleukin-6 concentrations and the -174 G>C and -572 G>C promoter polymorphisms of the interleukin-6 gene in patients with acute myocardial infarction treated with thrombolysis
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作者:
Bennermo, M
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Danderyd Hosp, Dept Med, SE-18288 Stockholm, SwedenDanderyd Hosp, Dept Med, SE-18288 Stockholm, Sweden
Bennermo, M
[1
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Held, C
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机构:Danderyd Hosp, Dept Med, SE-18288 Stockholm, Sweden
Held, C
Green, F
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机构:Danderyd Hosp, Dept Med, SE-18288 Stockholm, Sweden
Green, F
Strandberg, LE
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机构:Danderyd Hosp, Dept Med, SE-18288 Stockholm, Sweden
Strandberg, LE
Ericsson, CG
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机构:Danderyd Hosp, Dept Med, SE-18288 Stockholm, Sweden
Ericsson, CG
Hansson, LO
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机构:Danderyd Hosp, Dept Med, SE-18288 Stockholm, Sweden
Hansson, LO
Watkins, H
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机构:Danderyd Hosp, Dept Med, SE-18288 Stockholm, Sweden
Watkins, H
Hamsten, A
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机构:Danderyd Hosp, Dept Med, SE-18288 Stockholm, Sweden
Hamsten, A
Tornvall, P
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机构:Danderyd Hosp, Dept Med, SE-18288 Stockholm, Sweden
Tornvall, P
机构:
[1] Danderyd Hosp, Dept Med, SE-18288 Stockholm, Sweden
[2] Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden
[3] Karolinska Univ Hosp, Karolinska Inst, King Gustaf V Res Inst, Atherosclerosis Res Unit, Stockholm, Sweden
[4] Norrtaelje Hosp, Dept Med, Stockholm, Sweden
[5] Karolinska Univ Hosp, Dept Clin Chem, Stockholm, Sweden
[6] Univ Oxford, Dept Cardiovasc Med, Oxford, England
[7] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
The present study was performed to investigate the prognostic value of plasma interleukin-6 (IL-6) concentrations and promoter polymorphisms of the IL-6 gene in patients with acute myocardial infarction treated with thrombolysis. Two hundred and eight patients with myocardial infarction treated with thrombolysis were included and followed for 2-5 years. Plasma concentrations of IL-6 were measured at admission and 48 h after admission. Genotyping for the -174 G > C and -572 G > C IL-6 polymorphisms was performed. Patients who died of cardiovascular causes or suffered a new myocardial infarction during follow-up had increased plasma concentrations of IL-6 at admission (P < 0.002) and at 48 h after admission (P < 0.05) compared with patients who had an uneventful course. IL-6 levels above the median at admission were independently associated with a worse prognosis. No associations were found between IL-6 levels and the promoter polymorphisms. The -174 G > C polymorphism was not associated with cardiovascular death or a new myocardial infarction, whereas the -572 G > C polymorphism showed a borderline significant increase in risk (P = 0.05) in univariate analysis. In conclusion, the early IL-6, response during myocardial infarction is associated with prognosis in patients with Q-wave myocardial infarction, whereas no associations were found between IL-6 genotype and phenotype. (C) 2004 Elsevier Ireland Ltd. All rights reserved.