Acrolein, IL-6 and CRP as markers of silent brain infarction

被引：45

作者：

Yoshida, Madoka ^{[1
,4
]}

Tomitori, Hideyuki ^{[2
]}

Machi, Yoshiki ^{[1
]}

Katagiri, Daisuke ^{[1
]}

Ueda, Shiro ^{[1
]}

Horiguchi, Kentaro ^{[3
]}

Kobayashi, Eiichi ^{[3
]}

Saeki, Naokatsu ^{[3
]}

Nishimura, Kazuhiro ^{[1
]}

Ishii, Itsuko ^{[1
]}

Kashiwagi, Keiko ^{[2
]}

Igarashi, Kazuei ^{[1
,4
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, Chiba 2608675, Japan

[2] Chiba Inst Sci, Fac Pharm, Chiba, Japan

[3] Chiba Univ, Grad Sch Med, Chiba 2608675, Japan

[4] Chiba Univ, Amine Pharma Res Inst, Chiba 2608675, Japan

来源：

ATHEROSCLEROSIS | 2009年 / 203卷 / 02期

关键词：

Silent brain infarction; Acrolein; Inflammatory markers; Prediction; MYOCARDIAL-INFARCTION; POLYAMINE; STROKE; RISK; CYTOTOXICITY; SENSITIVITY; ACCURACY; PREDICTS; INCREASE; OXIDASE;

D O I：

10.1016/j.atherosclerosis.2008.07.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We found previously that increased levels of polyamine oxidase (PAO) [acetylpolyamine oxidase (AcPAO) Plus spermine oxidase (SMO)], and acrolein (CH2=CHCHO) are good markers of stroke. We then investigated whether silent brain infarction (SBI) can be detected by measuring acrolein, PAO, or other biomarkers. Several biomarkers were measured in the plasma of 53 normal subjects and 44 subjects with SBI. It was found that the levels of protein-conjugated acrolein (PC-Acro), interleukin-6 (IL-6) and C-reactive protein (CRP) were significantly higher in SBI than in normal Subjects. PAO was slightly higher in SBI than in normal Subjects. Since the probability of SBI was increased with age, values were analyzed including age as a factor. When the combined measurements of PC-Acro, IL-6 and CRP were evaluated together with age using a receiver operating characteristic curve, SBI was indicated with 89% sensitivity and 91% specificity. The results indicate that measurement of PC-Acro together with IL-6 and CRP makes it possible to identify SBI with high sensitivity and specificity. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：557 / 562

页数：6

共 30 条

[1] The blood-brain barrier: an overview - Structure, regulation, and clinical implications [J].

Ballabh, P ;

Braun, A ;

Nedergaard, M .

NEUROBIOLOGY OF DISEASE, 2004, 16 (01) :1-13

[2]

Brenner H, 1997, STAT MED, V16, P981, DOI 10.1002/(SICI)1097-0258(19970515)16:9<981::AID-SIM510>3.0.CO

[3]

2-N

[4] Hypoadiponectinemia is associated with ischemic cerebrovascular disease [J].

Chen, MP ;

Tsai, JCR ;

Chung, FM ;

Yang, SS ;

Hsing, LL ;

Shin, SJ ;

Lee, YJ .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (04) :821-826

[5] Statistics notes - Diagnostic tests 4: likelihood ratios [J].

Deeks, JJ ;

Altman, DG .

BRITISH MEDICAL JOURNAL, 2004, 329 (7458) :168-169

[6]

Ellenius J, 1997, CLIN CHEM, V43, P1919

[7] Serum S100B predicts a malignant course of infarction in patients with acute middle cerebral artery occlusion [J].

Foerch, C ;

Otto, B ;

Singer, OC ;

Neumann-Haefelin, T ;

Yan, B ;

Berkefeld, J ;

Steinmetz, H ;

Sitzer, M .

STROKE, 2004, 35 (09) :2160-2164

[8] THE MEANING AND USE OF THE AREA UNDER A RECEIVER OPERATING CHARACTERISTIC (ROC) CURVE [J].

HANLEY, JA ;

MCNEIL, BJ .

RADIOLOGY, 1982, 143 (01) :29-36

[9] Relations of serum high-sensitivity C-reactive protein and interleukin-6 levels with silent brain infarction [J].

Hoshi, T ;

Kitagawa, K ;

Yamagami, H ;

Furukado, S ;

Hougaku, H ;

Hori, M .

STROKE, 2005, 36 (04) :768-772

[10] ASYMPTOMATIC CAROTID LESIONS AND SILENT CEREBRAL INFARCTION [J].

HOUGAKU, H ;

MATSUMOTO, M ;

HANDA, N ;

MAEDA, H ;

ITOH, T ;

TSUKAMOTO, Y ;

KAMADA, T .

STROKE, 1994, 25 (03) :566-570

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