Detection of numerical chromosomal aberrations in malignant melanomas using fluorescence in situ hybridization

被引:20
作者
Matsuta, M
Imamura, Y
Matsuta, M
Sasaki, K
Kon, S
机构
[1] IWATE MED UNIV,SCH MED,DEPT OBSTET & GYNECOL,MORIOKA,IWATE 020,JAPAN
[2] IWATE MED UNIV,SCH MED,DEPT PATHOL,MORIOKA,IWATE 020,JAPAN
关键词
D O I
10.1111/j.1600-0560.1997.tb01581.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
To evaluate the numerical chromosomal aberration in malignant melanoma, we have applied fluorescence in situ hybridization (FISH) with repetitive DNA probes specific for chromosomes 1, 6, 7, 9, 10, and 17 on 24 fresh malignant melanomas (primary: 14, metastatic: 8). We defined a tumor that had copies with more than 3 spots as chromosomal gain. Chromosomal copy number gain was found in 40.9% of the cases for chromosome 7, 27.2% for chromosome 6, 27.2% for chromosome 17, 22.7% for chromosome 9 and 10, and 4.5% for chromosome 1. Monosomy was found in 54.5% of the cases for chromosome 10, 36.5% for chromosome 9, 27.2% for chromosome 6, 22.7% for chromosome 17, and 18.1% for chromosome 1 and 7. The most frequent numerical alterations were seen in chromosomes 6, 7, 9 and 10. Gain of chromosome 6 and 7 and/or losses of chromosome 9 and 10 may play an important role in the tumorigenesis and development of malignant melanomas.
引用
收藏
页码:201 / 205
页数:5
相关论文
共 19 条
[2]   ASSIGNMENT OF A LOCUS FOR FAMILIAL MELANOMA, MLM, TO CHROMOSOME-9P13-P22 [J].
CANNONALBRIGHT, LA ;
GOLDGAR, DE ;
MEYER, LJ ;
LEWIS, CM ;
ANDERSON, DE ;
FOUNTAIN, JW ;
HEGI, ME ;
WISEMAN, RW ;
PETTY, EM ;
BALE, AE ;
OLOPADE, OI ;
DIAZ, MO ;
KWIATKOWSKI, DJ ;
PIEPKORN, MW ;
ZONE, JJ ;
SKOLNICK, MH .
SCIENCE, 1992, 258 (5085) :1148-1152
[3]   DETECTION OF CHROMOSOME-ABERRATIONS IN THE HUMAN INTERPHASE NUCLEUS BY VISUALIZATION OF SPECIFIC TARGET DNAS WITH RADIOACTIVE AND NONRADIOACTIVE INSITU HYBRIDIZATION TECHNIQUES - DIAGNOSIS OF TRISOMY-18 WITH PROBE L1.84 [J].
CREMER, T ;
LANDEGENT, J ;
BRUCKNER, A ;
SCHOLL, HP ;
SCHARDIN, M ;
HAGER, HD ;
DEVILEE, P ;
PEARSON, P ;
VANDERPLOEG, M .
HUMAN GENETICS, 1986, 74 (04) :346-352
[4]   INCREASING EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN HUMAN MELANOCYTIC TUMOR PROGRESSION [J].
DEWIT, PEJ ;
MORETTI, S ;
KOENDERS, PG ;
WETERMAN, MAJ ;
VANMUIJEN, GNP ;
GIANOTTI, B ;
RUITER, DJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1992, 99 (02) :168-173
[5]   CLOSE SIMILARITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND V-ERB-B ONCOGENE PROTEIN SEQUENCES [J].
DOWNWARD, J ;
YARDEN, Y ;
MAYES, E ;
SCRACE, G ;
TOTTY, N ;
STOCKWELL, P ;
ULLRICH, A ;
SCHLESSINGER, J ;
WATERFIELD, MD .
NATURE, 1984, 307 (5951) :521-527
[6]  
DRACOPOLI NC, 1987, CANCER RES, V47, P3995
[7]   FORMATION AND DETECTION OF RNA-DNA HYBRID MOLECULES IN CYTOLOGICAL PREPARATIONS [J].
GALL, JG ;
PARDUE, ML .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1969, 63 (02) :378-&
[8]  
HOPMAN AH, 1987, AM J PATHOL, V135, P1105
[9]  
JENKINS RB, 1991, 4 INT C CHROM SOL TU
[10]   OPTIMIZING COMPARATIVE GENOMIC HYBRIDIZATION FOR ANALYSIS OF DNA-SEQUENCE COPY NUMBER CHANGES IN SOLID TUMORS [J].
KALLIONIEMI, OP ;
KALLIONIEMI, A ;
PIPER, J ;
ISOLA, J ;
WALDMAN, FM ;
GRAY, JW ;
PINKEL, D .
GENES CHROMOSOMES & CANCER, 1994, 10 (04) :231-243