Insulin-like growth factors in breast cancer

被引：22

作者：

Helle, SI ^{[1
]}

Lonning, PE ^{[1
]}

机构：

[1] HAUKELAND UNIV HOSP, DEPT ONCOL, N-5021 BERGEN, NORWAY

来源：

ACTA ONCOLOGICA | 1996年 / 35卷 / 05期

关键词：

D O I：

10.3109/02841869609083963

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Insulin-like growth factor (IGF)-I is one of the most potent mitogens to many breast cancer cell lines in vitro. Effective growth inhibition in vitro may be achieved by antibodies to the type I IGF receptor (IGF-IR) or by using antisense strategies. Most human breast cancers express IGF-IR in vivo. Thus, different therapeutic strategies aimed at inhibiting ligand stimulation of the IGF-IR may be an attractive treatment option against breast cancer. Several drugs commonly used in breast cancer influence the IGF system both in vitro and in vivo. While antioestrogens such as tamoxifen and droloxifene reduce the expression of IGF-IR in vitro and suppress plasma levels of IGF-I but elevate IGF-binding protein-1 in vivo, megestrol acetate may reduce the delivery of IGFs to the tissues by inhibition of IGPBP-3 protease activity.

引用

页码：19 / 22

页数：4

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