Immunologic basis of chronic allergic diseases: Clinical messages from the laboratory bench

被引:23
作者
Leung, DYM [1 ]
机构
[1] UNIV COLORADO, HLTH SCI CTR, DEPT PEDIAT, DENVER, CO 80262 USA
关键词
D O I
10.1203/00006450-199711000-00001
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
During the past decade there have been significant advances in our understanding of the mechanisms underlying allergic responses. Immediate hypersensitivity reactions are mediated primarily by mast cells in an IgE-dependent manner. After the local release of various mediators, proinflammatory cytokines, and chemokines, there is a cell-mediated response Chat is dominated by eosinophils and T lymphocytes. The majority of T cells in early allergic reactions are memory T cells secreting helper type 2 (T(H)2)-like cytokines, i.e. IL-4, IL-5, and IL-13, but not interferon-gamma. These cytokines regulate IgE synthesis and promote eosinophil differentiation and cell survival, thus contributing to allergic inflammatory responses. Failure to control immune activation early in the course of allergic inflammation may blunt the response to glucocorticoid therapy and contribute to long-term morbidity of disease. The identification of key cells and cytokines involved in the initiation and maintenance of allergic inflammation is likely to become an important therapeutic target in the future management of this important group of diseases.
引用
收藏
页码:559 / 568
页数:10
相关论文
共 115 条
  • [1] ABEHSIRAAMAR O, 1992, J IMMUNOL, V148, P3820
  • [2] MILK-INDUCED ECZEMA IS ASSOCIATED WITH THE EXPANSION OF T-CELLS EXPRESSING CUTANEOUS LYMPHOCYTE ANTIGEN
    ABERNATHYCARVER, KJ
    SAMPSON, HA
    PICKER, LJ
    LEUNG, DYM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (02) : 913 - 918
  • [3] EFFECTS OF LONG-TERM TREATMENT WITH AN INHALED CORTICOSTEROID ON GROWTH AND PULMONARY-FUNCTION IN ASTHMATIC-CHILDREN
    AGERTOFT, L
    PEDERSEN, S
    [J]. RESPIRATORY MEDICINE, 1994, 88 (05) : 373 - 381
  • [4] TRIAL OF CYCLOSPORINE IN CORTICOSTEROID-DEPENDENT CHRONIC SEVERE ASTHMA
    ALEXANDER, AG
    BARNES, NC
    KAY, AB
    [J]. LANCET, 1992, 339 (8789) : 324 - 328
  • [5] STEROID-RESISTANT ASTHMA - IMMUNOLOGICAL AND PHARMACOLOGICAL FEATURES
    ALVAREZ, J
    SURS, W
    LEUNG, DYM
    IKLE, D
    GELFAND, EW
    SZEFLER, SJ
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (03) : 714 - 721
  • [6] CIRCULATING ALLERGEN-REACTIVE T-CELLS FROM PATIENTS WITH ATOPIC-DERMATITIS AND ALLERGIC CONTACT-DERMATITIS EXPRESS THE SKIN-SELECTIVE HOMING RECEPTOR, THE CUTANEOUS LYMPHOCYTE-ASSOCIATED ANTIGEN
    BABI, LFS
    PICKER, LJ
    SOLER, MTP
    DRZIMALLA, K
    FLOHR, P
    BLASER, K
    HAUSER, C
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (05) : 1935 - 1940
  • [7] CC-CHEMOKINES IN ALLERGIC INFLAMMATION
    BAGGIOLINI, M
    DAHINDEN, CA
    [J]. IMMUNOLOGY TODAY, 1994, 15 (03): : 127 - 133
  • [8] GLUCOCORTICOID RECEPTOR-BETA, A POTENTIAL ENDOGENOUS INHIBITOR OF GLUCOCORTICOID ACTION IN HUMANS
    BAMBERGER, CM
    BAMBERGER, AM
    DECASTRO, M
    CHROUSOS, GP
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (06) : 2435 - 2441
  • [9] Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations
    Barnes, KC
    Neely, JD
    Duffy, DL
    Freidhoff, LR
    Breazeale, DR
    Schou, C
    Naidu, RP
    Levett, PN
    Renault, B
    Kucherlapati, R
    Iozzino, S
    Ehrlich, E
    Beaty, TH
    Marsh, DG
    [J]. GENOMICS, 1996, 37 (01) : 41 - 50
  • [10] ALLERGIC MODELS AND CYTOKINES
    BITTLEMAN, DB
    CASALE, TB
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 150 (05) : S72 - S76