Rassf Family of Tumor Suppressor Polypeptides

被引：95

作者：

Avruch, Joseph ^{[1
,4
,6
]}

Xavier, Ramnik ^{[3
,5
,6
]}

Bardeesy, Nabeel ^{[2
,6
]}

Zhang, Xian-Feng ^{[1
,4
,6
]}

Praskova, Maria ^{[1
,4
,6
]}

Zhou, Dawang ^{[1
,4
,6
]}

Xia, Fan ^{[1
,4
,6
]}

机构：

[1] Harvard Univ, Sch Med, Dept Mol Biol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Ctr Canc, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Diabet Unit, Med Serv, Boston, MA 02114 USA

[5] Harvard Univ, Sch Med, Gastrointestinal Unit, Med Serv, Boston, MA 02114 USA

[6] Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2009年 / 284卷 / 17期

基金：

美国国家卫生研究院;

关键词：

ORGAN SIZE CONTROL; MICROTUBULE STABILITY; BIOCHEMICAL-ANALYSIS; HIPPO PATHWAY; KINASE MST1; APOPTOSIS; PROTEIN; ACTIVATION; DOMAINS; NORE1;

D O I：

10.1074/jbc.R800073200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Rassf1-6 polypeptides each contain a Ras/Rap association domain, which enables binding to several GTP-charged Ras-like GTPases, at least in vitro or when overexpressed. The Ras/Rap association domains are followed by SARAH domains, which mediate Rassf heterodimerization with the Mst1/2 protein kinases. Rassf1A is unequivocally a tumor suppressor, and all Rassf proteins behave like tumor suppressors, exhibiting epigenetic silencing of expression in many human cancers and proapoptotic and/or anti-proliferative effects when re-expressed in tumor cell lines. Herein, we review the binding of the Rassf polypeptides to Ras-like GTPases and the Mst1/2 kinases and their role in Rassf function.

引用

页码：11001 / 11005

页数：5

共 40 条

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