MicroRNAs and mesenchymal stem cells: hope for pulmonary hypertension

被引：16

作者：

Zhu, Zhaowei ^{[1
]}

Fang, Zhenfei ^{[2
]}

Hu, Xinqun ^{[2
]}

Zhou, Shenghua ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Changsha 410011, Huan Province, Peoples R China

[2] Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Huan Province, Peoples R China

来源：

REVISTA BRASILEIRA DE CIRURGIA CARDIOVASCULAR | 2015年 / 30卷 / 03期

关键词：

Hypertension; Pulmonary; MicroRNAs; Mesenchymal Stem Cell Transplantation; ARTERIAL-HYPERTENSION; STROMAL CELLS; PROGENITOR CELLS; BONE-MARROW; CHRONIC HYPOXIA; GENE-THERAPY; LUNG; MONOCROTALINE; MECHANISM; RECEPTOR;

D O I：

10.5935/1678-9741.20150033

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Pulmonary hypertension is a devastating and refractory disease and there is no cure for this disease. Recently, microRNAs and mesenchymal stem cells emerged as novel methods to treat pulmonary hypertension. More than 20 kinds of microRNAs may participate in the process of pulmonary hypertension. It seems microRNAs or mesenchymal stem cells can ameliorate some symptoms of pulmonary hypertension in animals and even improve heart and lung function during pulmonary hypertension. Nevertheless, the relationship between mesenchymal stem cells, microRNAs and pulmonary hypertension is not clear. And the mechanisms underlying their function still need to be investigated. In this study we review the recent findings in mesenchymal stem cells - and microRNAs-based pulmonary hypertension treatment, focusing on the potential role of microRNAs regulated mesenchymal stem cells in pulmonary hypertension and the role of exosomes between mesenchymal stem cells and pulmonary hypertension.

引用

收藏

页码：380 / 385

页数：6

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