Effects of triphenyltin chloride on implantation and pregnancy in rats

The objective of this study was to characterize the adverse effects of triphenyltin chloride (TPTCl) during early pregnancy, Following successful mating, female rats were given TPTCl by gastric intubation at 3.1, 4.7, or 6.3 mg/kg on days 0 to 3 of pregnancy or at 6.3, 12.5, or 25.0 mg/kg on days 4 to 6 of pregnancy and were sacrificed on day 20 of pregnancy. In successfully mated females, TPTCl totally prevented implantation in a dose-dependent manner, The pregnancy rate was significantly decreased after administration of TPTCl on days 0 to 3 at 4.7 and 6.3 mg/kg and on days 4 to 6 at 12.5 and 25.0 mg/kg, In females having implantations, the numbers of implantations and live fetuses and the incidences of pre- and postimplantation loss and fetal malformations in the TPTCl-treated groups were comparable to the controls. It could be concluded that TPTCl during early pregnancy causes failure in implantation and TPTCl has greater antiimplantation effects when administered during earlier than later stages of blastogenesis. (C) 1997 Elsevier Science Inc.