A model for evaluating selective delivery of plasmid DNA to tumours via the vasculature

被引：15

作者：

Dass, CR ^{[1
]}

Burton, MA ^{[1
]}

机构：

[1] Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2678, Australia

来源：

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | 2002年 / 17卷 / 05期

关键词：

tumour; plasmid; vasculature; microsphere;

D O I：

10.1089/108497802760804727

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A comparative study of plasmid DNA delivery in a newly established rat renal solid tumour model was undertaken. Free plasmid, plasmids bound to microspheres, and plasmids complexed with liposomes were selectively delivered to tumours via arterial catheterisation. Forty-eight hours post delivery, tumour to normal kidney tissue chloramphenicol acetyltransferase expression ratios were as follows: free (1.8:1), microspherical (3.9:1), and liposomal (1.2:1). Microspheres were able to selectively deliver the plasmids to tumours, whereas cationic liposomes distributed the plasmids to both kidney parenchymal and tumour cells. This tumour model has the potential of screening delivery vehicles as well as therapeutic agents for the capacity of selective delivery to tumours via the vasculature.

引用

页码：501 / 505

页数：5

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