Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance

被引:190
作者
Sangster, TA
Lindquist, S
Queitsch, C
机构
[1] Harvard Univ, Bauer Ctr Genom Res, Cambridge, MA 02138 USA
[2] Univ Chicago, Committee Genet, Chicago, IL 60637 USA
[3] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
关键词
D O I
10.1002/bies.20020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The environmentally responsive molecular chaperone Hsp90 assists the maturation of many key regulatory proteins. An unexpected consequence of this essential biochemical function is that genetic variation can accumulate in genomes and can remain phenotypically silent until Hsp90 function is challenged. Notably, this variation can be revealed by modest environmental change, establishing an environmentally responsive exposure mechanism. The existence of diverse cryptic polymorphisms with a plausible exposure mechanism in evolutionarily distant lineages has implications for the pace and nature of evolutionary change. Chaperone-mediated storage and release of genetic variation is undoubtedly rooted in protein-folding phenomena. As we discuss, proper protein folding crucially affects the trajectory from genotype to phenotype. Indeed, the impact of protein quality-control mechanisms and other fundamental cellular processes on evolution has heretofore been overlooked. A true understanding of evolutionary processes will require an integration of current evolutionary paradigms with the many new insights accruing in protein science. (C) 2004 Wiley Periodicals, Inc.
引用
收藏
页码:348 / 362
页数:15
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