Short sequence repeats in microbial pathogenesis and evolution

被引：60

作者：

van Belkum, A ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr Rotterdam, Dept Med Microbiol & Infect Dis, NL-3015 GD Rotterdam, Netherlands

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 56卷 / 9-10期

关键词：

short sequence repeats; variable number of tandem repeat loci; slipped strand mispairing; molecular epidemiology; microbial evolution; Haemophilus influenzae; Helicobacter pylori; Candida albicans;

D O I：

10.1007/s000180050019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Repetitive DNA is ubiquitous in microbial genomes. Different classes of short sequence repeats (SSRs) have been identified and demonstrated to be generally heterogeneous in a locus-dependent manner, reflected in variation in the number of repeat units present at a given genomic site or by sequence heterogeneity among individual units. Both types of variability can be used to assess intra-species genetic diversity. Repeat variability often affects the coding potential of the region in which the repetitive element is located. This implies that determination of the primary structure of variable numbers of tandem repeats can be used for epidemiological identification purposes, and also for the analysis of gene function. Precise assessment of SSR structure can also generate insight into the regulation of gene expression. Together, DNA repeat analysis in microbial species provides information on both functional and evolutionary aspects of genetic diversity among microbial isolates.

引用

页码：729 / 734

页数：6

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