T lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen

被引:203
作者
Quayle, AJ
Xu, C
Mayer, KH
Anderson, DJ
机构
[1] HARVARD UNIV, BRIGHAM & WOMENS HOSP, SCH MED, DEPT OBSTET GYNECOL & REPROD BIOL, BOSTON, MA 02115 USA
[2] FENWAY COMMUNITY HLTH CTR, BOSTON, MA USA
[3] MEM HOSP, DEPT MED, PAWTUCKET, RI 02860 USA
[4] BROWN UNIV, SCH MED, PROVIDENCE, RI 02912 USA
关键词
D O I
10.1086/516541
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The cellular fraction of semen contains spermatozoa, immature germ cells, leukocytes, and epithelial cells. Recent evidence implicates seminal cells as a major source of sexually transmitted human immunodeficiency virus (HIV) in semen, but the identity and infectious potential of infected cells remains poorly understood. HIV provirus was found in 75% of viable semen cell samples by polymerase chain reaction and in 88% of paired blood cell samples from HIV-seropositive men. When semen cell subpopulations were isolated by an immunomagnetic bead technique, T cells were found to be most commonly HIV-infected (75% of samples), followed by macrophages (38% of samples). Viral DNA was never detected in motile spermatozoa or immature germ cell populations. Semen leukocytes proliferated in response to mitogenic and antigenic challenge and produced p24 following stimulation with irradiated allogeneic cells. These data provide evidence that both T cells and macrophages, but not germ cells, are cellular vectors of HIV transmission in semen.
引用
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页码:960 / 968
页数:9
相关论文
共 64 条
[1]  
ANDERSON DJ, 1990, CONRAD W S, P167, DOI 10.1017/CBO9780511666582.008
[2]   EFFECTS OF DISEASE STAGE AND ZIDOVUDINE THERAPY ON THE DETECTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN SEMEN [J].
ANDERSON, DJ ;
OBRIEN, TR ;
POLITCH, JA ;
MARTINEZ, A ;
SEAGE, GR ;
PADIAN, N ;
HORSBURGH, CR ;
MAYER, KH .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 267 (20) :2769-2774
[3]   WHITE BLOOD-CELLS AND HIV-1 IN SEMEN FROM VASECTOMIZED SEROPOSITIVE MEN [J].
ANDERSON, DJ ;
POLITCH, JA ;
MARTINEZ, A ;
VANVOORHIS, BJ ;
PADIAN, NS ;
OBRIEN, TR .
LANCET, 1991, 338 (8766) :573-574
[4]  
ANDERSON DJ, 1992, J NIH RES, V4, P104
[5]  
ANDERSON P, 1990, J IMMUNOL, V144, P574
[6]   CLUSTER OF CASES OF THE ACQUIRED IMMUNE-DEFICIENCY SYNDROME - PATIENTS LINKED BY SEXUAL CONTACT [J].
AUERBACH, DM ;
JAFFE, HW ;
CURRAN, JW ;
DARROW, WW .
AMERICAN JOURNAL OF MEDICINE, 1984, 76 (03) :487-492
[7]   SERUM LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) AND SOLUBLE TNF RECEPTORS IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION - CORRELATIONS TO CLINICAL, IMMUNOLOGICAL, AND VIROLOGICAL PARAMETERS [J].
AUKRUST, P ;
LIABAKK, NB ;
MULLER, F ;
LIEN, E ;
ESPEVIK, T ;
FROLAND, SS .
JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (02) :420-424
[8]   HIV-PARTICLES IN SPERMATOZOA OF PATIENTS WITH AIDS AND THEIR TRANSFER INTO THE OOCYTE [J].
BACCETTI, B ;
BENEDETTO, A ;
BURRINI, AG ;
COLLODEL, G ;
CECCARINI, EC ;
CRISA, N ;
DICARO, A ;
ESTENOZ, M ;
GARBUGLIA, AR ;
MASSACESI, A ;
PIOMBONI, P ;
RENIERI, T ;
SOLAZZO, D .
JOURNAL OF CELL BIOLOGY, 1994, 127 (04) :903-914
[9]   DETECTION OF HIV-1 PROVIRAL DNA IN SPERM FROM HIV-1-INFECTED MEN [J].
BAGASRA, O ;
FARZADEGAN, H ;
SESHAMMA, T ;
OAKES, JW ;
SAAH, A ;
POMERANTZ, RJ .
AIDS, 1994, 8 (12) :1669-1674
[10]  
BAGASRA O, 1988, J ACQ IMMUN DEF SYND, V1, P431