In vivo lipid peroxidation responses of tissues in lead-treated Swiss mice

A single intraperitoneal injection of lead acetate (200 mg/kg body weight) increased the lipid peroxidation potential (LPP) measured as thiobarbituric acid-reactive substance (TBA-RS) in different tissues of Swiss mice. All the tissues taken for experimentation, generated significantly higher amount of TBA-RS in lead-treated mice when compared with the respective control value. However, none of the tissues could correspond to the control value after the lapse of four weeks posttreatment. Possibilities of differential responsiveness of tissues to generate lipid peroxides in lead-treated mice have been discussed.