Novel C-2 substituted carbapenem derivatives .1. Synthesis and biological activity of non-aromatic heterocyclic derivatives

被引:4
作者
Burton, G [1 ]
Clear, NJC [1 ]
Eglington, AJ [1 ]
Guest, AW [1 ]
Hunt, E [1 ]
Naylor, A [1 ]
Pearson, MJ [1 ]
Takle, AK [1 ]
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND
关键词
D O I
10.7164/antibiotics.49.1258
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A new series of carbapenems, having a saturated or partially unsaturated heterocycle at C-2, has been synthesised. The in vitro antibacterial activity of these compounds and their stability to human dehydropeptidase-1 (DHP-1) are described. The stereochemistry of the C-2 side-chain and the presence of a double bond in the heterocycle were shown to have significant effects on the stabilities of the compounds to DHP-1.
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收藏
页码:1258 / 1265
页数:8
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