Novel C-2 substituted carbapenem derivatives .1. Synthesis and biological activity of non-aromatic heterocyclic derivatives

被引：4

作者：

Burton, G ^{[1
]}

Clear, NJC ^{[1
]}

Eglington, AJ ^{[1
]}

Guest, AW ^{[1
]}

Hunt, E ^{[1
]}

Naylor, A ^{[1
]}

Pearson, MJ ^{[1
]}

Takle, AK ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 12期

关键词：

D O I：

10.7164/antibiotics.49.1258

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new series of carbapenems, having a saturated or partially unsaturated heterocycle at C-2, has been synthesised. The in vitro antibacterial activity of these compounds and their stability to human dehydropeptidase-1 (DHP-1) are described. The stereochemistry of the C-2 side-chain and the presence of a double bond in the heterocycle were shown to have significant effects on the stabilities of the compounds to DHP-1.

引用

页码：1258 / 1265

页数：8

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