Dynamic infrared imaging of cutaneous melanoma and normal skin in patients treated with BNCT

被引：50

作者：

Santa Cruz, G. A. ^{[1
]}

Bertotti, J. ^{[2
]}

Marin, J. ^{[2
]}

Gonzalez, S. J. ^{[1
,3
]}

Gossio, S. ^{[4
]}

Alvarez, D. ^{[5
]}

Roth, B. M. C. ^{[6
]}

Menendez, P. ^{[6
]}

Pereira, M. D.

Albero, M. ^{[7
]}

Cubau, L. ^{[7
]}

Orellano, P. ^{[7
]}

Liberman, S. J. ^{[1
]}

机构：

[1] Comis Nacl Energia Atom, Dpto Instrumentac & Control, RA-1429 Buenos Aires, DF, Argentina

[2] Univ Favaloro, RA-1078 Buenos Aires, DF, Argentina

[3] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina

[4] Univ Buenos Aires, Fac Ciencias Exactas & Nat, RA-1428 Buenos Aires, DF, Argentina

[5] Fdn Favaloro, RA-1093 Buenos Aires, DF, Argentina

[6] Inst Oncol Angel H Roffo, RA-1417 Buenos Aires, DF, Argentina

[7] INVAP SE, San Carlos De Bariloche, Rio Negro, Argentina

来源：

APPLIED RADIATION AND ISOTOPES | 2009年 / 67卷 / 7-8期

关键词：

Infrared thermography; Skin reaction; Melanoma;

D O I：

10.1016/j.apradiso.2009.03.093

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We recently initiated a program aimed to investigate the suitability of dynamic infrared imaging for following-up nodular melanoma patients treated with BNCT. The reason that makes infrared imaging attractive is the fact that it constitutes a functional and non-invasive imaging method, providing information on the normal and abnormal physiologic response of the nervous and vascular systems, as well as the local metabolic rate and inflammatory processes that ultimately appear as differences in the skin temperature. An infrared camera, with a focal plane array of 320 x 240 uncooled ferroelectric detectors is employed, which provides a video stream of the infrared emission in the 7-14 mu m wavelength band. A double blackbody is used as reference for absolute temperature calibration. After following a protocol for patient preparation and acclimatization, a basal study is performed. Subsequently, the anatomic region of interest is subjected to a provocation test (a cold stimulus), which induces an autonomic vasoconstriction reflex in normal structures, thus enhancing the thermal contrast due to the differences in the vasculature of the different skin regions. Radiation erythema reactions and melanoma nodules possess typically a faster temperature recovery than healthy, non-irradiated skin. However, some other non-pathological structures are also detectable by infrared imaging, (e.g. scars, vessels, arteriovenous anastomoses and injuries), thus requiring a multi-study comparison in order to discriminate the tumor signal. Besides the superficial nodules, which are readily noticeable by infrared imaging, we have detected thermal signals that are coincident with the location of non-palpable nodules, which are observable by CT and ultrasound. Diffuse regions of fast temperature recovery after a cold stimulus were observed between the third and sixth weeks post-BNCT. concurrent with the clinical manifestation of radiation erythema. The location of the erythematous visible and infrared regions is consistent with the 3D dosimetry calculations. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：S54 / S58

页数：5