Synthesis of homo-C-D4T and homo-C-thymidine

被引：19

作者：

Doboszewski, B ^{[1
]}

机构：

[1] UNIV FED PERNAMBUCO,DEPT ANTIBIOT,BR-50739 RECIFE,PE,BRAZIL

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期

关键词：

D O I：

10.1080/07328319708006130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

beta-C-Vinyl glycoside of D-arabinofuranose was converted to the beta-C-hydroxymethyl glycoside 12 which was condensed with N-3-benzoyl thymine under Mitsunobu conditions to furnish homo-C-analog 14 of the 2',3'-dideoxy-2',3'-didehydrothymidine (D4T). Synthesis of the homo-C-thymidine 18 was accomplished by the same procedure from compound 15.

引用

页码：1049 / 1052

页数：4

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