Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T

被引:97
作者
Jia, Zhiyun [1 ]
Wang, Yuqing [1 ]
Huang, Xiaoqi [1 ]
Kuang, Weihong [2 ]
Wu, Qizhu [1 ]
Lui, Su [1 ]
Sweeney, John A. [3 ,4 ]
Gong, Qiyong [1 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Radiol, HMRRC, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Psychiat, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[3] Univ Texas Southwestern, Dept Psychiat, Dallas, TX USA
[4] Univ Texas Southwestern, Dept Pediat, Dallas, TX USA
来源
JOURNAL OF PSYCHIATRY & NEUROSCIENCE | 2014年 / 39卷 / 03期
关键词
DEEP BRAIN-STIMULATION; INTERNAL CAPSULE; ORBITOFRONTAL CORTEX; ANTERIOR LIMB; DISORDER; TRACTOGRAPHY; ASSOCIATION; BIPOLAR; PREDICTORS; THALAMUS;
D O I
10.1503/jpn.130023
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: The neurobiology of suicide is largely unknown. Studies of white matter tracts in patients with a history of suicidal behaviour have shown alteration in the left anterior limb of the internal capsule (ALIC). Our aim was to determine whether particular target fields of fibre projections through the ALIC are affected in depressed patients who recently attempted suicide. Methods: We studied patients with major depressive disorder (MDD) with and without a history of suicide attempts and healthy controls using diffusion tensor imaging (DTI) and deterministic tractography to generate fibre tract maps for each participant. Tract voxels were coded as being unique to the left ALIC. We compared the mean percentage of fibres projecting to relevant brain regions in the 3 groups using analysis of covariance. Results: We included 63 patients with MDD (23 with and 40 without a history of suicide attempts) and 46 controls in our study. Both groups of depressed patients had reduced fibre projections through the ALIC to the left medial frontal cortex, orbitofrontal cortex and thalamus. Those with a history of suicide attempts had greater abnormalities than those without suicide attempts in the left orbitofrontal cortex and thalamus. Limitations: Diffusion tensor imaging deterministic tracking is unable to distinguish between afferent and efferent pathways, limiting our ability to distinguish the directionality of altered fibre tracts. Conclusion: Frontothalamic loops passing through the ALIC are abnormal in patients with depression and significantly more abnormal in depressed patients with a history of suicide attempts than in those without a history of suicide attempts. Abnormal projections to the orbitofrontal cortex and thalamus may disrupt affective and cognitive functions to confer a heightened vulnerability for suicidal behaviour.
引用
收藏
页码:170 / 177
页数:8
相关论文
共 49 条
[1]   MRI correlates of suicide attempt history in unipolar depression [J].
Ahearn, EP ;
Jamison, KR ;
Steffens, DC ;
Cassidy, F ;
Provenzale, JM ;
Lehman, A ;
Weisler, RH ;
Carroll, BJ ;
Krishnan, KRR .
BIOLOGICAL PSYCHIATRY, 2001, 50 (04) :266-270
[2]   Mapping of fiber orientation in human internal capsule by means of polarized light and confocal scanning laser microscopy [J].
Axer, H ;
Von Keyserlingk, DG .
JOURNAL OF NEUROSCIENCE METHODS, 2000, 94 (02) :165-175
[3]  
Basser PJ, 2000, MAGNET RESON MED, V44, P625, DOI 10.1002/1522-2594(200010)44:4<625::AID-MRM17>3.0.CO
[4]  
2-O
[5]   Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging [J].
Behrens, TEJ ;
Johansen-Berg, H ;
Woolrich, MW ;
Smith, SM ;
Wheeler-Kingshott, CAM ;
Boulby, PA ;
Barker, GJ ;
Sillery, EL ;
Sheehan, K ;
Ciccarelli, O ;
Thompson, AJ ;
Brady, JM ;
Matthews, PM .
NATURE NEUROSCIENCE, 2003, 6 (07) :750-757
[6]  
Bertolote Jose Manoel, 2002, World Psychiatry, V1, P181
[7]   Depression in Parkinson's disease: Convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus [J].
Cardoso, Ellison Fernando ;
Maia, Fernanda Martins ;
Fregni, Felipe ;
Myczkowski, Martin Luis ;
Melo, Luciano M. ;
Sato, Joao R. ;
Marcolin, Marco Antonio ;
Rigonatti, Sergio P. ;
Cruz, Antonio Cesario, Jr. ;
Barbosa, Egberto Reis ;
Amaro, Edson, Jr. .
NEUROIMAGE, 2009, 47 (02) :467-472
[8]   The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates [J].
Coplan, Jeremy D. ;
Abdallahh, Chadi G. ;
Tang, Cheuk Y. ;
Mathew, Sanjay J. ;
Martinez, Jose ;
Hof, Patrick R. ;
Smith, Eric L. P. ;
Dwork, Andrew J. ;
Perera, Tarique D. ;
Pantol, Gustavo ;
Carpenter, David ;
Rosenblum, Leonard A. ;
Shungu, Dikoma C. ;
Gelernter, Joel ;
Kaffman, Arie ;
Jackowski, Andrea ;
Kaufman, Joan ;
Gorman, Jack M. .
NEUROSCIENCE LETTERS, 2010, 480 (02) :93-96
[9]   Association between symptom severity and internal capsule volume in obsessive-compulsive disorder [J].
de Souza Duran, Fabio Luis ;
Hoexter, Marcelo Queiroz ;
Valentejr, Antonio Augusto, Jr. ;
Miguel, Euripedes Constantino ;
Busatto, Geraldo Filho .
NEUROSCIENCE LETTERS, 2009, 452 (01) :68-71
[10]   Quantitative evaluation of 10 tractography algorithms on a realistic diffusion MR phantom [J].
Fillard, Pierre ;
Descoteaux, Maxime ;
Goh, Alvina ;
Gouttard, Sylvain ;
Jeurissen, Ben ;
Malcolm, James ;
Ramirez-Manzanares, Alonso ;
Reisert, Marco ;
Sakaie, Ken ;
Tensaouti, Fatima ;
Yo, Ting ;
Mangin, Jean-Francois ;
Poupon, Cyril .
NEUROIMAGE, 2011, 56 (01) :220-234