An Efficient and Modular Route to Sequence- Defined Polymers Appended to DNA

被引：120

作者：

Edwardson, Thomas G. W. ^{[1
]}

Carneiro, Karina M. M. ^{[1
]}

Serpell, Christopher J. ^{[1
]}

Sleiman, Hanadi F. ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 0B8, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 18期

基金：

加拿大自然科学与工程研究理事会;

关键词：

amphiphiles; DNA; polymers; self-assembly; solid-phase synthesis; SYNTHETIC-POLYMERS; PEPTIDE-SYNTHESIS;

D O I：

10.1002/anie.201310937

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inspired by biological polymers, sequence-controlled synthetic polymers are highly promising materials that integrate the robustness of synthetic systems with the information-derived activity of biological counterparts. Polymer-biopolymer conjugates are often targeted to achieve this union; however, their synthesis remains challenging. We report a stepwise solid-phase approach for the generation of completely monodisperse and sequence-defined DNA-polymer conjugates using readily available reagents. These polymeric modifications to DNA display self-assembly and encapsulation behavioras evidenced by HPLC, dynamic light scattering, and fluorescence studieswhich is highly dependent on sequence order. The method is general and has the potential to make DNA-polymer conjugates and sequence-defined polymers widely available.

引用

页码：4567 / 4571

页数：5

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