The serotonin1A receptor agonist 8-OHDPAT reverses △9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

被引：25

作者：

Inui, K

Egashira, N

Mishima, K

Yano, A

Matsumoto, Y

Hasebe, N

Abe, K

Hayakawa, K

Ikeda, T

Iwasaki, K

Fujiwara, M ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Neuropharmacol, Fukuoka 8140180, Japan

[2] Kyushu Womens Jr Coll, Dept Sch Nursing, Kitakyushu, Fukuoka, Japan

[3] Miyazaki Univ, Miyazaki Med Coll, Dept Obstet & Gynecol, Miyazaki 8891692, Japan

来源：

NEUROTOXICITY RESEARCH | 2004年 / 6卷 / 02期

关键词：

triangle(9)-tetrahydrocannabinol; spatial memory; acetylcholine; serotonin; 5-HT1A receptor; 8-OHDPAT; hippocampus;

D O I：

10.1007/BF03033218

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT), a 5-HT1A receptor agonist, on both Delta(9)-tetrahydrocannabinol-induced spatial memory impairment in an 8-arm radial maze, and the reduction of acetylcholine release in the dorsal hippocampus as assessed by in vivo microdialysis in rats. A 6 mg/kg i.p. dose of Delta(9)-tetrahydrocannabinol impaired spatial memory in the 8-arm radial maze and decreased the acetylcholine release in the dorsal hippocampus. 8-OHDPAT, at very low doses of 0.1-0.3 mug/kg, reversed both the impairment of spatial memory and the decrease in acetylcholine release induced by Delta(9)-tetrahydrocannabinol. These findings suggest that low doses of 8-OHDPAT may improve Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory by enhancing acetylcholine release in the dorsal hippocampus.

引用

页码：153 / 157

页数：5

共 17 条

[1] Low doses of 8-OH-DPAT prevent the impairment of spatial learning caused by intrahippocampal scopolamine through 5-HT1A receptors in the dorsal raphe [J].