Novel 3-(4-piperidinylthio)-1H-indoles as potent nonopioid orally active central analgesics

被引：17

作者：

Potin, D ^{[1
]}

Parnet, V ^{[1
]}

Teulon, JM ^{[1
]}

Camborde, F ^{[1
]}

Caussade, F ^{[1
]}

Meignen, J ^{[1
]}

Provost, D ^{[1
]}

Cloarec, A ^{[1
]}

机构：

[1] Labs UPSA, F-92506 Rueil Malmaison, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)00102-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-(4-piperidinylthio)-1H-indoles was synthesized and evaluated in mice in the phenylbenzoquinone(PBQ)-induced writhing and hot plate tests. Most of these compounds are good analgesics with activities comparable to that of morphine. Among them compound 1i (UP 237-61), which has a strong serotonin binding profile, has an interesting antinociceptive activity which is not reversed by naloxone. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：805 / 809

页数：5

共 20 条

[1] PIPERIDINE DERIVATIVES WITH A SULFUR-CONTAINING FUNCTION IN 4- POSITION [J].