Enantioselective synthesis of 1-deoxy-D-gulonojirimycin from a phenylglycinol-derived lactam

被引：14

作者：

Amat, M ^{[1
]}

Huguet, M

Llor, N

Bassas, O

Gómez, AM

Bosch, J

Badia, J

Baldoma, L

Aguilar, J

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

[2] Univ Barcelona, Fac Pharm, Dept Biochem, E-08028 Barcelona, Spain

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 28期

关键词：

azasugars; phenylglycinol; chiral bicyclic lactams; polyhydroxypiperidines; enantioselective synthesis;

D O I：

10.1016/j.tetlet.2004.05.089

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclocondensation of (R)-phenylglycinol with appropriately gamma-substituted delta-oxo acid derivatives provides bicyclic lactams from which the enantioselective synthesis of 1-deoxy-D-gulonojirimycin has been reported. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5355 / 5358

页数：4

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