Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease

被引：22

作者：

Kessoku, Takaomi ^{[1
]}

Ogawa, Yuji ^{[1
]}

Yoneda, Masato ^{[1
]}

Imajo, Kento ^{[1
]}

Sumida, Yoshio ^{[2
]}

Eguchi, Yuichiro ^{[3
]}

Fujii, Hideki ^{[4
]}

Hyogo, Hideyuki

Ono, Masafumi ^{[5
,6
]}

Suzuki, Yasuaki ^{[7
]}

Kawaguchi, Takumi ^{[8
]}

Chayama, Kazuaki ^{[5
]}

Tanaka, Saiyu ^{[9
]}

Fujimoto, Kazuma ^{[10
]}

Anzai, Keizo ^{[10
]}

Saibara, Toshiji ^{[6
]}

Sata, Michio ^{[8
]}

Itoh, Yoshito ^{[2
]}

Nakajima, Atsushi ^{[1
]}

Okanoue, Takeshi ^{[11
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Yokohama, Kanagawa 2360004, Japan

[2] Kyoto Prefectural Univ Med, Dept Mol Gastroenterol & Hepatol, Kyoto 6020841, Japan

[3] Saga Med Sch, Dept Gen Med, Saga 8498501, Japan

[4] Osaka City Univ, Dept Hepatol, Osaka 5588585, Japan

[5] Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7300053, Japan

[6] Kochi Med Sch, Dept Gastroenterol & Hepatol, Kochi 7838505, Japan

[7] Nayoro City Gen Hosp, Dept Gastroenterol, Nayoro, Hokkaido 0968511, Japan

[8] Kurume Univ, Sch Med, Dept Gastroenterol, Kurume, Fukuoka 8300011, Japan

[9] Nara City Hosp, Dept Internal Med, Nara 6348522, Japan

[10] Univ Hosp, Dept Internal Med, Saga 8498577, Japan

[11] Saiseikai Suita Hosp, Dept Gastroenterol & Hepatol, Osaka 5650862, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 29期

基金：

日本学术振兴会;

关键词：

Nonalcoholic fatty liver disease; Cirrhosis; Fibrosis; Platelet; Albumin; Alanine aminotransferase ratio; NATURAL-HISTORY; STEATOHEPATITIS; FIBROSIS; VALIDATION; NAFLD;

D O I：

10.3748/wjg.v20.i29.10108

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

AIM: To investigate a simple noninvasive scoring system for predicting liver cirrhosis in nonalcoholic fatty liver disease (NAFLD) patients. METHODS: A total of 1048 patients with liver-biopsy-confirmed NAFLD were enrolled from nine hepatology centers in Japan (stage 0, 216; stage 1, 334; stage 2, 270; stage 3, 190; stage 4, 38). The weight and height of the patients were measured using a calibrated scale after requesting the patients to remove their shoes and any heavy clothing. Venous blood samples were obtained in the morning after the patients had fasted overnight for 12 h. Laboratory evaluation was performed in all patients. Statistical analysis was conducted using SPSS version 12.0. Continuous variables were expressed as mean +/- SD. RESULTS: The optimal cutoff value of platelet count, serum albumin, and amino-transferase/alanine aminotransferase ratio (AAR) was set at < 15.3 10(4)/mu L, < 4.0 g/dL, and > 0.9, respectively, by the receiver operating characteristic curve. These three variables were combined in an unweighted sum (platelet count = 1 point, serum albumin = 1 point, AAR = 1 point) to form an easily calculated composite score for predicting cirrhosis in NAFLD patients, called the PLALA (platelet, albumin, AAR) score. The diagnosis of PLALA >= 2 had sufficient accuracy for detecting liver cirrhosis in NAFLD patients. CONCLUSION: The PLALA score may be an ideal scoring system for detecting cirrhosis in NAFLD patients with sufficient accuracy and simplicity to be considered for clinical use. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：10108 / 10114

页数：7

共 35 条

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