Amine-salt-controlled, catalytic asymmetric conjugate addition of various amines and asymmetric protonation

被引：128

作者：

Hamashima, Y ^{[1
]}

Somei, H ^{[1
]}

Shimura, Y ^{[1
]}

Tamura, T ^{[1
]}

Sodeoka, M ^{[1
]}

机构：

[1] Tohoku Univ, IMRAM, Sendai, Miyagi 9808577, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 11期

关键词：

D O I：

10.1021/ol0493711

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The combined use of chiral Pd complex 2 and amine salt enabled completely regulated release of free nucleophilic amine. Under these conditions, an efficient catalytic asymmetric conjugate addition of various amines was achieved to afford beta-amino acid derivatives in high chemical yields with up to 98% ee. Furthermore, a highly enantioselective protonation in 1,4-addition of amine was also developed.

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页码：1861 / 1864

页数：4

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