TRPA1 and Cold Transduction: An Unresolved Issue?

被引:85
作者
Caspani, Ombretta [2 ]
Heppenstall, Paul A. [1 ]
机构
[1] EMBL Monterotondo, I-00015 Monterotondo, Italy
[2] Charite Univ Med Berlin, Klin Anaesthesiol & Operat Intens Med, D-12200 Berlin, Germany
关键词
ION-CHANNEL TRPA1; SENSORY NEURONS; TRPM8; PHARMACOLOGY; CONTRIBUTES; ACTIVATION; EXPRESSION; MENTHOL; FIBERS; ANKTM1;
D O I
10.1085/jgp.200810136
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
TRPA1 was originally characterized as a cold-activated ion channel; however, since the initial description there has been some disagreement about its role in cold sensation. Here, we review the literature on the function of TRPA1 as a cold sensor. Many studies have demonstrated that TRPA1 can be activated by cold when expressed in heterologous systems, but its role as a cold sensor in native peripheral sensory neurons remains uncertain. We argue that TRPA1 is activated indirectly by cold via a background Ca2+ influx seen in cells during cooling. This background cold response is present in most heterologous cell types, but not in sensory neurons. Thus, we propose that cold sensitivity of TRPA1 is indirect and is dependent on cellular context.
引用
收藏
页码:245 / 249
页数:5
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