anti-selective SMP-catalyzed direct asymmetric Mannich-type reactions:: synthesis of functionalized amino acid derivatives

被引：132

作者：

Córdova, A

Barbas, CF

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 43期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(02)01772-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first (S)-2-methoxymethylpyrrolidine (SMP)-catalyzed direct asymmetric Mannich-type reactions of unmodified aldehydes with N-PMP-protected alpha-imino ethyl glyoxylate are described. The reaction proceeded in a highly anti-selective manner (dr up to 19:1) with enantioselectivities between 74 and 92%. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：7749 / 7752

页数：4

共 37 条

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[3]

2-E

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