Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression

被引：114

作者：

Lefort, K

Dotto, GP

机构：

[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

[2] Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA

[3] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 05期

关键词：

Notch1; keratinocyte; differentiation; tumorigenesis;

D O I：

10.1016/j.semcancer.2004.04.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncogenesis is closely linked to abnormalities in cell differentiation. Notch signaling provides an important form of intercellular communication involved in cell fate determination, stem cell potential and differentiation. Here we review the role of this pathway in the integrated growth/differentiation control of the keratinocyte cell type, and the maintenance of normal skin homeostasis. In parallel with the pro-differentiation function of Notch I in keratinocytes, we discuss recent evidence pointing to a tumor suppressor function of this gene in both mouse skin and human cervical carcinogenesis. The possibility that Notch signaling elicits signals with a duality of growth positive and negative function will be discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：374 / 386

页数：13

共 181 条

[1] Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1 [J].