Force-induced deformations and stability of biological bonds

被引：49

作者：

Pereverzev, Yuriy V. ^{[1
]}

Prezhdo, Oleg V. ^{[1
]}

机构：

[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA

来源：

PHYSICAL REVIEW E | 2006年 / 73卷 / 05期

关键词：

D O I：

10.1103/PhysRevE.73.050902

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

A deformation model of the forced-induced dissociation of biological bonds is developed. A simple illustration shows that protein deformations can change the receptor-ligand interaction linearly with applied force at small forces, either increasing or decreasing the bond stability, and that a minor external work can lead to notable changes in the interaction energy. The deformation-induced increase of bond stability is illustrated with the remarkable catch-bond phenomenon in P and L selections. Additionally, the model rationalizes the frequently seen disparity between the bond dissociation rates of many free complexes and the zero-force asymptotic rates measured by force spectroscopy.

引用

页数：4

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