Analysis of aluminum-26 labeled aluminum chlorohydrate

A small quantity of aluminum chlorohydrate (ACH), the active ingredient in antiperspirants, was labeled with the radioisotope Al-26. This labeled drug will be used in future studies to measure the absorption of aluminum from antiperspirant use. The purpose of this study was to demonstrate that the technique used to make the Al-26-labeled ACH resulted in a uniformly labeled complex, and therefore any measurement of Al-26 would be indicative of total aluminum. The labeled ACH was fractionated using gel filtration chromatography into 72 evenly spaced samples. The fractions were then measured for Al-26 and total aluminum content using accelerator mass spectrometry (AMS) and inductively coupled plasma atomic emission spectroscopy (ICP-AES). Results indicate that the ACH is uniformly labeled. (C) 1999 Elsevier Science Inc. All rights reserved.