UV-B radiation microphototherapy. An elective treatment for segmental vitiligo

被引:40
作者
Lotti, TM
Menchini, G
Andreassi, L [1 ]
机构
[1] Univ Siena, Dept Dermatol, Policlin Scotte, Siena, Italy
[2] Univ Florence, Dept Dermatol, Florence, Italy
关键词
vitiligo; UV-B; therapy;
D O I
10.1111/j.1468-3083.1999.tb00861.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background Vitiligo is a common disease of unknown cause that produces disfiguring white patches of depigmentation. Previous studies have suggested the effectiveness of UV-B radiation in generalized vitiligo (GV) therapy, but there was no evidence to support the same role for segmental vitiligo (SV). Objective The purpose of this study was to use UV-B radiation exclusively on vitiligo patches of individuals affected by SV to evaluate the effectiveness of this therapy. Subjects and methods Eight individuals with SV were treated for 6 months with a new device called BIOSKIN(R) that can produce a focused beam of UV-B (microphoto-therapy) on vitiligo patches only. Photographs of the subjects were taken at the beginning of the therapy and once a month thereafter for 6 months. The response to treatment was estimated in two comparable photographs using planimetry. A control group of eight individuals matched for sex and age was treated with placebo, using the same device but not releasing any kind of detectable light. Results After 6 months of microphototherapy five subjects of the eight studied achieved normal pigmentation on more than 75% of the treated areas. In particular, three of these were totally repigmented. Two individuals achieved 50-75% pigmentation of the treated areas, and only one showed less than 50% repigmentation (Table 3). In the control group only one patient showed moderate repigmentation (less than 50%) (Table 3) (Fig. 3). Conclusion W-B microphototherapy seems highly effective in restoring pigmentation in patients affected by vitiligo. As no side-effects have been observed, this could represent the treatment of choice in the limited (segmental) forms of vitiligo. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
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页码:102 / 108
页数:7
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