Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides

被引：18

作者：

Adams, Yvonne

Freeman, Craig

Schwartz-Albiez, Reinhard

Ferro, Vito

Parish, Christopher R.

Andrews, Katherine T. ^{[1
]}

机构：

[1] Queensland Inst Med Res, Clin Trop Med Lab, Div Infect Dis & Immunol, Herston, Qld 4029, Australia

[2] Queensland Inst Med Res, ACITHN, Herston, Qld 4029, Australia

[3] Heidelberg Univ, Inst Hyg, Abt Parasitol, D-69120 Heidelberg, Germany

[4] Australian Natl Univ, Canc & Vasc Biol Grp, Div Immunol & Genet, John Curtin Sch Med Res, Canberra, ACT 2601, Australia

[5] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany

[6] Progen Ind Ltd, Drug Design Grp, Darra, Qld 4076, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 08期

关键词：

D O I：

10.1128/AAC.00313-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase 11 anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 mu M) and demonstrated modest adhesion inhibition to cell surface CSA.

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收藏

页码：2850 / 2852

页数：3

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