CD1d-and MR1-restricted invariant T cells: of mice and men

被引：104

作者：

Treiner, Emmanuek

Lantz, Olivier

机构：

[1] Inst Curie, INSERM, U653, Immunol Lab, F-70005 Paris, France

[2] Fac Med, INSERM, E0351, Immunol Lab, F-80036 Amiens, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2006年 / 18卷 / 05期

关键词：

D O I：

10.1016/j.coi.2006.07.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD1d-restricted natural killer T cells and MR1-restricted mucosal associated invariant T (MATT) cells constitute two subsets of unconventional T cells that are phylogenetically conserved. Therefore, they are thought to play an essential role within the immune system. MR1-restricted MATT cell selection is dependent upon B cells, and their accumulation in the gut lamina propria and mesenteric lymph node requires the commensal bacterial flora. These features suggest that MATT cells could be involved in tolerance or immunity to infections in the gut. As for natural killer T cells, the recent identification of one endogenous ligand, isoglobotrihexosylceramide, and of a family of bacterial agonists is an important advance for understanding their thymic selection and their role during infections.

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页码：519 / 526

页数：8

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