GES-11, a Novel Integron-Associated GES Variant in Acinetobacter baumannii

被引:101
作者
Moubareck, Carole [1 ]
Bremont, Sylvie [1 ]
Conroy, Marie-Christine [2 ]
Courvalin, Patrice [1 ]
Lambert, Thierry [1 ]
机构
[1] Inst Pasteur, Unite Agents Antibacteriens, Ctr Natl Reference Resistance Antibiot, F-75724 Paris 15, France
[2] CHU, Bacteriol Lab, F-54035 Nancy, France
关键词
SPECTRUM BETA-LACTAMASE; KLEBSIELLA-PNEUMONIAE; MOLECULAR CHARACTERIZATION; PSEUDOMONAS-AERUGINOSA; CARBAPENEM RESISTANCE; QUINOLONE RESISTANCE; ENTEROBACTERIA; EPIDEMIOLOGY;
D O I
10.1128/AAC.00072-09
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
New extended-spectrum beta-lactamase GES-11 was detected in Acinetobacter baumannii BM4674. The enzyme conferred resistance to beta-lactams, including aztreonam, and reduced susceptibility to carbapenems. The structural gene was part of a class 1 integron borne by self-transferable plasmid pIP847. GES-type beta-lactamases have not been reported previously in A. baumannii.
引用
收藏
页码:3579 / 3581
页数:3
相关论文
共 21 条
[1]   Acinetobacter spp, as nosocomial pathogens: Microbiological, clinical, and epidemiological features [J].
BergogneBerezin, E ;
Towner, KJ .
CLINICAL MICROBIOLOGY REVIEWS, 1996, 9 (02) :148-+
[2]  
BIRNBOIM HC, 1979, NUCLEIC ACIDS RES, V7, P1513
[3]  
*COM ANT SOC FRANC, 2009, COMM 2009
[4]   Molecular characterization of a new class 3 integron in Klebsiella pneumoniae [J].
Correia, M ;
Boavida, F ;
Grosso, F ;
Salgado, MJ ;
Lito, LM ;
Cristino, JM ;
Mendo, S ;
Duarte, A .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (09) :2838-2843
[5]   Modes and modulations of antibiotic resistance gene expression [J].
Depardieu, Florence ;
Podglajen, Isabelle ;
Leclercq, Roland ;
Collatz, Ekkehard ;
Courvalin, Patrice .
CLINICAL MICROBIOLOGY REVIEWS, 2007, 20 (01) :79-+
[6]   Molecular characterization of a novel class 1 integron containing blaGES-1 and a fused product of aac(3)-ib/Aac(6′)-Ib′ gene cassettes in Pseudomonas aeruginosa [J].
Dubois, W ;
Poirel, L ;
Marie, C ;
Arpin, C ;
Nordmann, P ;
Quentin, C .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) :638-645
[7]   Comparative genomics of multidrug resistance in Acinetobacter baumannii [J].
Fournier, Pierre-Edouard ;
Vallenet, David ;
Barbe, Valerie ;
Audic, Stephane ;
Ogata, Hiroyuki ;
Poirel, Laurent ;
Richet, Herve ;
Robert, Catherine ;
Mangenot, Sophie ;
Abergel, Chantal ;
Nordmann, Patrice ;
Weissenbach, Jean ;
Raoult, Didier ;
Claverie, Jean-Michel .
PLOS GENETICS, 2006, 2 (01) :62-72
[8]   Genetic environment of quinolone resistance gene qnrB2 in a complex sul1-type integron in the newly described Salmonella enterica serovar Keurmassar [J].
Garnier, Fabien ;
Raked, Nabil ;
Gassama, Amy ;
Denis, Francois ;
Ploy, Marie-Cecile .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (09) :3200-3202
[9]   Acinetobacter baumannii:: a universal threat to public health? [J].
Giamarellou, Helen ;
Antoniadou, Anastasia ;
Kanellakopoulou, Kyriaki .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2008, 32 (02) :106-119
[10]   Qnr-type quinolone resistance in extended-spectrum beta-lactamase producing enterobacteria in Abidjan, Ivory Coast [J].
Guessennd, N. ;
Bremont, S. ;
Gbonon, V. ;
Kacou-NDouba, A. ;
Ekaza, E. ;
Lambert, T. ;
Dosso, M. ;
Courvalin, P. .
PATHOLOGIE BIOLOGIE, 2008, 56 (7-8) :439-446