Potent inhibition of human Hepatitis B virus replication by a host factor Vps4

被引：55

作者：

Chua, Pong Kian

Lin, Min-Hui

Shih, Chiaho ^{[1
]}

机构：

[1] Univ Texas, Med Branch, Dept Pathol, Inst Human Infect & Immunol, Galveston, TX 77555 USA

[2] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

来源：

VIROLOGY | 2006年 / 354卷 / 01期

基金：

美国国家卫生研究院;

关键词：

hepatitis B virus; HBV; replication; host factor; vacuolar protein sorting; Vps4; HepG2; Huh7; anti-viral therapy; virion secretion;

D O I：

10.1016/j.virol.2006.07.018

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vps4 is a host factor known to be involved in cellular vacuolar protein sorting. We report here that HBV replication and secretion can be significantly inhibited by Vps4 dominant negative, ATPase-defective, mutants K173Q and E228Q. In contrast, wild-type Vps4 at low dose can inhibit HBV replication more effectively in human hepatoblastoma cell line HepG2, than in human hepatoma cell line Huh7. To our knowledge, this is the first demonstration of an anti-HBV potential of dominant negative mutants of a protein sorting host factor Vps4. (c) 2006 Elsevier Inc. All rights reserved.

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页码：1 / 6

页数：6

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