TNF-α and chronic fatigue syndrome

被引：98

作者：

Moss, RB

Mercandetti, A

Vojdani, A

机构：

[1] Immune Res Corp, Carlsbad, CA 92008 USA

[2] Immunosci Lab Inc, Beverly Hills, CA 90211 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 1999年 / 19卷 / 05期

关键词：

chronic fatigue syndrome; tumor necrosis factor-alpha; inflammation; cytokines;

D O I：

10.1023/A:1020595709352

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Based upon the clinical presentation of chronic fatigue syndrome (CFS), we hypothesized that proinflammatory cytokines may play a role in the pathogenesis of the disease. We therefore undertook a retrospective cross-sectional study to examine the role of TNF-cr in patients with CFS. Our results suggest a significant increase serum TNF-cr in patients with CFS (P < 0.0001) compared to non-CFS controls. This study supports the further examination of the role of proinflammatory mediators in CFS. Furthermore, the clinical testing of TNF-alpha blockers and other antiinflammatory agents for the treatment of this disease is warranted.

引用

页码：314 / 316

页数：3

共 12 条

[1]

[Anonymous], 1999, FUNDAMENTAL IMMUNOLO

[2]

Bauditz J, 1998, NEW ENGL J MED, V338, P334

[3]

Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome [J].